New Study Links Head Injuries to Viruses in Alzheimer’s 

A recent study has found that repeated head injuries, such as concussions, may reactivate dormant viruses in the brain, increasing the risk of Alzheimer’s disease (AD) and other neurodegenerative conditions. Researchers discovered that even mild brain trauma could trigger harmful changes linked to memory loss and cognitive decline. 

Previous studies had already highlighted the role of common viruses, such as herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV), in the development of AD. HSV-1, responsible for cold sores, can remain dormant in human cells for years. When reactivated, it can cause changes resembling those seen in AD, including amyloid plaque-like formations, neuroinflammation, and reduced brain functionality. 

The latest research from Science Signaling, found that repeated mild impacts, like concussions, can reactivate dormant HSV-1 in the brain. This leads to inflammation and damage linked to memory loss. Blocking a molecule called Interleukin-1 beta (IL-1β) may help prevent this, offering hope for new treatments.

Professor Ruth Itzhaki, a leading expert who has studied the link between HSV-1 and Alzheimer’s for over 30 years, explained: 

 
“Head injuries are already recognised as a major risk factor, as are the cumulative effects of common infections, for conditions such as Alzheimer’s and dementia, but this is the first time we have been able to demonstrate a mechanism for that process. 

What we’ve discovered is that these injuries can reactivate a dormant virus, HSV-1, setting off inflammation which, in the brain, would lead to the very changes we see in Alzheimer’s patients.” 

The findings highlight the importance of understanding risk factors and mechanisms behind Alzheimer’s to develop early intervention and preventative treatments, particularly for those prone to repeated head injuries. 

Supporting Those Affected by Brain Injuries 

As specialists in serious injury cases, including brain injuries, we understand the challenges survivors face. We work with organisations like Brain Injury Group and Headway Lincolnshire, offering support ranging from rehabilitation and emotional support to legal advice. 

If you or a loved one has suffered a brain injury, we can help you access the guidance and assistance you need. As a medico-legal agency, we work with a panel of experts across all specialties to produce medico-legal reports.